The growing awareness of the importance of national systems of innovation on countries’ development led to an increased availability of instruments designed to measure and compare the innovative capacity of countries. Such instruments provide policymakers with a panoply of relevant information, with which they can stimulate innovation within their territory, thereby increasing national competitiveness. Among the most used innovation indices, the Global Innovation Index stands out by explicitly distinguishing innovation inputs and outputs. Drawing from the Global Innovation Index input-output framework and extant literature on innovation, we intend to answer the question: Which innovation inputs are more strongly related to innovative outputs? Thus, deriving policy implications aimed at improving Portugal’s innovative readiness. Based on a conceptual model, we developed a panel dataset, grounded on the Global Innovation Index framework, composed by 92 countries during the period 2013-2018, and analysed it through a series of multiple regression techniques.